In a recent study published in Nature Communications, a group of researchers explored how Death Induced by Survival gene Elimination (DISE) through the analysis of ribonucleic acid (RNA)-induced ...

circRNA, circular RNA; dsRNA, double-stranded RNA; lncRNA, long non-coding RNA; mRNA, messenger RNA; miRNA, microRNA; ncRNA, non-coding RNA; pre-miRNA, precursor miRNA; pri-miRNA, primary miRNA; RISC, ...

A research team from The Hong Kong University of Science and Technology (HKUST) has made a breakthrough discovery in understanding the molecular machinery of RNA silencing. The team uncovered how the ...

RNA interference (RNAi) is a type of posttranscriptional genetic regulation that occurs naturally in the cytoplasm to protect the cell against excess and foreign RNAs. Double-stranded RNA (dsRNA), an ...

The discovery of RNAi dates back to the 1990s when researchers observed unexpected gene silencing in plants and fungi. In 1998, Andrew Fire and Craig Mello published a groundbreaking study ...

Viroid replication generates dsRNA intermediates, which are processed by Dicer into 21- to 25-nucleotide siRNAs. These siRNAs are then incorporated into siRNA – ribonuclease complexes (RISC). If the ...

In a series of studies published over the past year, a research team at The Wistar Institute has provided considerable insight into the world of miRNAs. In their first study, which appeared last year ...