T cell receptors (TCRs) are fundamental to the adaptive immune system, playing a pivotal role in recognising and responding to pathogenic challenges. Generated through the process of V(D)J ...

Just before the pandemic took center stage in 2020, scientists at a T cell memory conference convened to discuss a less than traditional topic: nomenclature. Prior to the event, the workshop ...

Investigators led by Navdeep Chandel, PhD, the David W. Cugell, MD, Professor of Medicine in the Division of Pulmonary and Critical Care, have discovered how the metabolism of mitochondria supports ...

For decades, cancer immunotherapy has focused primarily on CD8 + cytotoxic T lymphocytes as the main executors of tumor cell killing. However, growing clinical and single-cell sequencing evidence ...

As 2025 comes to a close, the editors at The Scientist asked researchers to reflect on the biggest breakthroughs in cell biology this year. They named advances in everything from embryo models for ...

Chimeric antigen receptor (CAR) T cell-based therapy has greatly improved cancer treatment, especially for hematologic cancers. 1 By providing T cells with synthetic receptors that target tumor ...

The generation of durable CD8+ T cell memory following infection or vaccination is essential for protection against future encounters with the same or related pathogens. This process has traditionally ...

The US held a majority share in the global car-t cell therapy market and is expected to grow at CAGR of 31.6 % during the forecast period. Demonstrated high remission rates in certain ...